PPP2R4 antibody (AA 1-323)

Catalog No. ABIN1682265

Product Details anti-PPP2R4 Antibody

Target: PPP2R4 (Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4))

Binding Specificity: AA 1-323

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPP2R4 antibody is un-conjugated

Application: Immunofluorescence (IF)

Sequence: MAEGERQPPP DSSEEAPPAT QNFIIPKKEI HTVPDMGKWK RSQAYADYIG FILTLNEGVK GKKLTFEYRV SEAIEKLVAL LNTLDRWIDE TPPVDQPSRF GNKAYRTWYA KLDEEAENLV ATVVPTHLAA AVPEVAVYLK ESVGNSTRID YGTGHEAAFA AFLCCLCKIG VLRVDDQIAI VFKVFNRYLE VMRKLQKTYR MEPAGSQGVW GLDDFQFLPF IWGSSQLIDH PYLEPRHFVD EKAVNENHKD YMFLECILFI TEMKTGPFAE HSNQLWNISA VPSWSKVNQG LIRMYKAECL EKFPVIQHFK FGSLLPIHPV TSG

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human Ser/thr-PP2A activator (PTPA) (NP_821067.1).

Isotype: IgG

Application Details

Application Notes: IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-PPP2R4 antibody (ABIN1682265)

Jiang, Cao, Wang, Li, Liu, Lv, Li, Mi: "Cysteine transporter SLC3A1 promotes breast cancer tumorigenesis." in: Theranostics, Vol. 7, Issue 4, pp. 1036-1046, (2017) (PubMed).

Wang, Gan, Wang, Wu, Cao, Zhu, Xu, Wang, Han, Li, Ye, Zhao, Mi: "Cancer-associated Fibroblasts Promote Irradiated Cancer Cell Recovery Through Autophagy." in: EBioMedicine, Vol. 17, pp. 45-56, (2017) (PubMed).

Target Details for PPP2R4

Target: PPP2R4 (Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4))

Alternative Name: PPP2R4 (PPP2R4 Products)

Synonyms: PP2A antibody, PR53 antibody, PTPA antibody, 2610042B21Rik antibody, C77440 antibody, N28142 antibody, PTPRA antibody, Ppp2r4 antibody, fc23d07 antibody, ppp2r4 antibody, wu:fc23d07 antibody, zgc:92766 antibody, pp2a antibody, ppp2r4.L antibody, pr53 antibody, ptpa antibody, protein phosphatase 2 phosphatase activator antibody, protein phosphatase 2 protein activator antibody, protein phosphatase 2 phosphatase activator L homeolog antibody, PTPA antibody, Ptpa antibody, ptpa antibody, ptpa.L antibody

Background: Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.,PTPA,PP2A,PPP2R4,PR53,Signal Transduction,PI3K-Akt Signaling Pathway,Cell Biology & Developmental Biology,TGF-b-Smad Signaling Pathway,ESC Pluripotency and Differentiation,PPP2R4

Molecular Weight: 31 kDa/33 kDa/36 kDa/40 kDa

Gene ID: 5524

UniProt: Q15257

Pathways: PI3K-Akt Signaling, M Phase, Hepatitis C, Toll-Like Receptors Cascades