Recombinant EGFR (Matuzumab Biosimilar) antibody (Extracellular Domain)
Reactivity: Human
FACS, WB, BR
Host: Rabbit
Chimeric
unconjugated
Recombinant Antibody
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- Target See all EGFR (Matuzumab Biosimilar) products
- EGFR (Matuzumab Biosimilar)
- Antibody Type
- Recombinant Antibody
- Binding Specificity
- Extracellular Domain
- Reactivity
- Human
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Host
- Rabbit
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Clonality
- Chimeric
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Conjugate
- This EGFR (Matuzumab Biosimilar) antibody is un-conjugated
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Application
- Flow Cytometry (FACS), Western Blotting (WB), Blocking Reagent (BR)
- Specificity
- Binds to human EGFR.
- Characteristics
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OriginalSpeciesName: Human
OriginalFormat: IgG1
- Purification
- Purified antibody.
- Purity
- > 98 % as determined by SDS-PAGE
- Endotoxin Level
- Endotoxin is < 1.0 EU/mg as determined by the LAL method
- Immunogen
- The parental mouse antibody was generated by immunizing BALB/c mice intraperitoneally with A431 cells in phosphate buffered saline (PBS). Later on the humanzied version of the antibody was created by grafting CDRs of the murine antibody onto human constant regions.
- Isotype
- IgG kappa
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anti-EGFR (Matuzumab Biosimilar) (Extracellular Domain) antibody
Reactivity: Human FACS, WB, BR Host: Human Monoclonal unconjugated Recombinant Antibody
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- Application Notes
- This antibody binds to human EGFR at a side distinct frm the antigen binding site, preventing conformational re-arrangement required for dimerization, a process essential for high-affinitiy ligand binding (Schmiedel 2008).
- Comment
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This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % Proclin 300.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- Target
- EGFR (Matuzumab Biosimilar)
- Abstract
- EGFR (Matuzumab Biosimilar) Products
- Background
- ErbB-1, ERBB1, HER1, EGF, Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, EMD72000, mAb425, 425, mAb 425
- UniProt
- P00533
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