Recombinant TNF alpha (Adalimumab Biosimilar) antibody
Reactivity: Human
ELISA, IF, IHC, BR
Host: Human
Monoclonal
D2E7
unconjugated
Recombinant Antibody
(1 reference)-
- Target See all TNF alpha (Adalimumab Biosimilar) products
- TNF alpha (Adalimumab Biosimilar)
- Antibody Type
- Recombinant Antibody
- Reactivity
- Human
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Host
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Human
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Clonality
- Monoclonal
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Conjugate
- This TNF alpha (Adalimumab Biosimilar) antibody is un-conjugated
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Application
- ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Blocking Reagent (BR)
- Specificity
- Binds to soluble TNF-alpha, but not to lymphotoxin (TNF beta).
- Characteristics
-
OriginalSpeciesName: Human
OriginalFormat: IgG1
- Purification
- Purified antibody.
- Purity
- > 98 % as determined by SDS-PAGE
- Endotoxin Level
- Endotoxin is < 1.0 EU/mg as determined by the LAL method
- Immunogen
- This antibody was generated by affinity maturation from the 2SD4 scFv, which in turn was selected on human TNF alpha by guided phage-display technology, using the murine anti-hTNF alpha antibody Mab32 as a template (c.f. also US Patent 6090382).
- Clone
- D2E7
- Isotype
- IgG1 kappa
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- Application Notes
- Adalimumab binds specifically to TNF and neutralizes the biological function of TNF by blocking its interaction with the p55 and p75 cell surface TNF receptors.
- Comment
-
NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % Proclin 300.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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-
: "Scaling eukaryotic cell-free protein synthesis achieved with the versatile and high-yielding tobacco BY-2 cell lysate." in: Biotechnology and bioengineering, (2023) (PubMed).
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: "Scaling eukaryotic cell-free protein synthesis achieved with the versatile and high-yielding tobacco BY-2 cell lysate." in: Biotechnology and bioengineering, (2023) (PubMed).
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- Target
- TNF alpha (Adalimumab Biosimilar)
- Abstract
- TNF alpha (Adalimumab Biosimilar) Products
- Synonyms
- DIF antibody, TNF-alpha antibody, TNFA antibody, TNFSF2 antibody, tumor necrosis factor antibody, TNF antibody
- Target Type
- Biosimilar
- Background
- Tumor necrosis factor alpha
- UniProt
- P01375
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