IMPACT antibody (AA 21-120)

Catalog No. ABIN5675564

Product Details anti-IMPACT Antibody

Target: IMPACT (Impact Homolog (IMPACT))

Binding Specificity: AA 21-120

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IMPACT antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Sheep,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human IMPACT

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for IMPACT

Target: IMPACT (Impact Homolog (IMPACT))

Alternative Name: IMPACT (IMPACT Products)

Synonyms: zgc:103672 antibody, Ximpact antibody, impact-A antibody, RWDD5 antibody, impact-a antibody, E430016J11Rik antibody, impact RWD domain protein antibody, impact antibody, impact RWD domain protein L homeolog antibody, impact, RWD domain protein antibody, IMPACT antibody, impact antibody, EDI_298310 antibody, impact.L antibody, Impact antibody

Background:

Synonyms: Protein IMPACT, IMPACT, Imprinted and ancient gene protein homolog

Background: Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis (By similarity). May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis (By similarity). Through its action on GCN2, may also facilitate neuritogenesis (By similarity).

Gene ID: 55364

UniProt: Q9P2X3