AGE antibody

Catalog No. ABIN5680158

Product Details anti-AGE Antibody

Target: AGE (Advanced Glycation End Products (AGE))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AGE antibody is un-conjugated

Application: ELISA

Specificity: Advanced Glycation End Products (AGE), cross-reactivity BSA-AGE, HSA-AGE <1 %

Cross-Reactivity (Details): Human, rat. Broad reactivity with advanced glycation end products (AGE) in many species.

Characteristics: This antibody is suitable for the detection of different AGE products in tissues, tissue extracts and body fluids. Long-term incubation of proteins with glucose leads, through Schiff's base and Amadori rearrangement products, to the formation of advanced glycation end products (AGE) which are characterized by fluorescence, brown color and inter- and intra-molecular cross-linking. Recent immunological studies using anti-AGE antibodies demonstrated the presence of AGE in (i) human lens, (ii) renal proximal tubules in patients with diabetic nephropathy and chronic renal failure, (iii) atherosclerotic lesions of arterial walls, (iv) ß2-microglobulin of carpal tunnel amyloid fibril deposits in patients with hemodialysis-related amyloidosis and (v) brain tissues of patients with Alzheimer's disease. These results suggested the potential role of AGE in normal aging and age-enhanced disease processes. Advanced Glycation End Products (AGE), cross-reactivity BSA and HSA <1 % .

Purification: Protein A affinity purified IgG

Immunogen: Advanced Glycation End Products /BSA/HSA

Isotype: IgG

Application Details

Application Notes: human lens, arteriosclerotic plaques,ELISA, IHC not established,60 min at RT or 18 hr at 2-8 °C,(liquid conc.) ELISA app. 1 μg/mL, (IHC 5-10 μg/mL)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS 0.05 M,  pH 7.15, 0.85 % NaCl, 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for AGE

Target: AGE (Advanced Glycation End Products (AGE))

Alternative Name: AGE, Advanced Glycation End Products (AGE Products)

Synonyms: RBP antibody, RNBP antibody, renin binding protein antibody, RENBP antibody

Target Type: Chemical