Ancient Ubiquitous Protein 1 antibody (AA 229-410)

Catalog No. ABIN5684097

Product Details anti-Ancient Ubiquitous Protein 1 Antibody

Target: Ancient Ubiquitous Protein 1 (Aup1)

Binding Specificity: AA 229-410

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This Ancient Ubiquitous Protein 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS), Neutralization (Neut)

Purification: purified

Immunogen: Purified recombinant fragment of human AUP1 (AA: 229-410) expressed in E. coli.

Clone: 7G4A6

Isotype: IgG2b

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: N/A, FCM: N/A, IHC: N/A

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

Target Details for Ancient Ubiquitous Protein 1

Target: Ancient Ubiquitous Protein 1 (Aup1)

Alternative Name: AUP1 (Aup1 Products)

Synonyms: AA589454 antibody, wu:fc37d06 antibody, zgc:73323 antibody, zgc:77755 antibody, AUP1, lipid droplet regulating VLDL assembly factor antibody, ancient ubiquitous protein 1 antibody, ancient ubiquitous protein 1 S homeolog antibody, AUP1 antibody, aup1 antibody, Aup1 antibody, aup1.S antibody

Background: The protein encoded this gene is involved in several pathways including quality control of misfolded proteins in the endoplasmic reticulum and lipid droplet accumulation. Lipid droplets are organelles in the cytoplasm that store neutral lipids such as cholesterol esters and trigylycerides to prevent the overabundance of free cholesterol and fatty acids in cells, but also to act as storage for other metabolic processes, such as membrane biogenesis. Reduced expression of this gene results in reduced lipid droplet clustering, a function that is dependent on ubiquitination of the protein. This protein contains multiple domains including a hydrophobic N-terminal domain, an acetyltranferase domain, a ubiquitin-binding CUE domain, and a UBE2B2-binding domain (G2BR). Alternative splicing results in multiple transcript variants.

Molecular Weight: 53 kDa

Gene ID: 550

HGNC: 27180