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Caspase 2 antibody

CASP2 Reactivity: Human, Mouse, Rat, Dog, Monkey WB, ELISA, IHC, IP, ICC, FACS Host: Rat Monoclonal 11B4 unconjugated
Catalog No. ABIN5690633
  • Target See all Caspase 2 (CASP2) Antibodies
    Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))
    Reactivity
    • 99
    • 38
    • 25
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Dog, Monkey
    Host
    • 91
    • 6
    • 4
    Rat
    Clonality
    • 80
    • 21
    Monoclonal
    Conjugate
    • 59
    • 7
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This Caspase 2 antibody is un-conjugated
    Application
    • 73
    • 34
    • 23
    • 14
    • 14
    • 14
    • 10
    • 8
    • 7
    • 6
    • 5
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC), Flow Cytometry (FACS)
    Specificity
    Recognizes an epitope in the p19 subunit of human, mouse, rat, monkey and dog caspase-2. Detects bands of ~51  kDa (procaspase-2), ~32  kDa and ~18  kDa (cleavage products) by Western blot.
    Purity
    > 95% (SDS-PAGE)
    Immunogen
    Recombinant human caspase-2 (p19 subunit).
    Clone
    11B4
    Isotype
    IgG2a kappa
    Top Product
    Discover our top product CASP2 Primary Antibody
  • Application Notes
    Immunoprecipitation: (1-5 μg/mL) . Western Blot: (1-2 μg/mL) . Optimal conditions must be determined individually for each application.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Liquid. In PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Stable for at least 1 year after receipt when stored at -20°C.
  • Target
    Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))
    Alternative Name
    Caspase-2 (CASP2 Products)
    Synonyms
    xCaspase-2 antibody, Caspase-2 antibody, ICH-1 antibody, Nedd2 antibody, CASP-2 antibody, ICH1 antibody, NEDD-2 antibody, NEDD2 antibody, PPP1R57 antibody, ICH-1L/1S antibody, ICH1L1S antibody, caspase 2 antibody, caspase 2 L homeolog antibody, caspase-2 antibody, CASP2 antibody, casp2.L antibody, CpipJ_CPIJ008254 antibody, Casp2 antibody
    Background
    Caspase-2 is a Class I caspase with a long prodomain necessary for nuclear localization. Upon activation of the apoptotic pathway, the procaspase is cleaved into smaller fragments. Caspase-2 is the nuclear apoptotic respondent to cellular genotoxic stress or mitotic catastrophe and is involved in the activation cascade of caspases responsible for apoptosis execution. Activation occurs upon recruitment to a complex containing a p53-induced death domain protein, PIDD. This suggests caspase-2 can be a nuclear initiator caspase with a requirement for caspase-9 and caspase-3 activation in downstream apoptotic events. In apoptotic pathways resulting from UV-induced DNA damage, processing of caspase-2 occurs downstream of mitochondrial dysfunction and of caspase-9 and caspase-3 activation, extending a possible role for caspase-2 as a parallel effector caspase.
    Gene ID
    835
    UniProt
    P42575
    Pathways
    Apoptosis, Caspase Cascade in Apoptosis, Neurotrophin Signaling Pathway
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