Neurexin 1 antibody (AA 141-294) (DyLight 488)

Catalog No. ABIN7354637

Product Details anti-Neurexin 1 Antibody (DyLight 488)

Target: Neurexin 1 (NRXN1)

Binding Specificity: AA 141-294

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neurexin 1 antibody is conjugated to DyLight 488

Application: Flow Cytometry (FACS)

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG Polyclonal Anti-Human Neurexin 1 Antibody DyLight® 488 Conjugated, Flow Validated.

Immunogen: E. coli-derived human Neurexin 1 recombinant protein (Position: D141-E294).

Application Details

Application Notes:

Application Details: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: At 2-8°C for one year. Protect from light. Do not freeze.

Target Details for Neurexin 1

Target: Neurexin 1 (NRXN1)

Alternative Name: NRXN1 (NRXN1 Products)

Synonyms: Hs.22998 antibody, PTHSL2 antibody, SCZD17 antibody, CG7050 antibody, CT21808 antibody, Dmel\\CG7050 antibody, Nrx antibody, Nrx1 antibody, dnrx antibody, dnrx-1 antibody, nrx antibody, Nrxn1b antibody, NRXN1 antibody, Nrx-1 antibody, GB13455 antibody, GB18754 antibody, 1700062G21Rik antibody, 9330127H16Rik antibody, A230068P09Rik antibody, mKIAA0578 antibody, neurexin 1 antibody, Neurexin 1 antibody, neurexin I antibody, neurexin 1b antibody, neurexin 1a antibody, NRXN1 antibody, Nrx-1 antibody, Nrxn1 antibody, nrxn1 antibody, nrxn1b antibody, nrxn1a antibody

Background:

Synonyms: Neurexin-1-beta, Neurexin I-beta, NRXN1

Background: Neurexin-1-alpha is a protein that in humans is encoded by the NRXN1 gene. This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia.

UniProt: P58400

Pathways: Synaptic Membrane, Skeletal Muscle Fiber Development