Periaxin antibody (AA 1-91) (DyLight 488)

Catalog No. ABIN7354670

The Rabbit Polyclonal anti-Periaxin antibody has been validated for FACS. It is suitable to detect Periaxin in samples from Human.

Quick Overview for Periaxin antibody (AA 1-91) (DyLight 488) (ABIN7354670)

Target: Periaxin (PRX)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Periaxin antibody is conjugated to DyLight 488

Application: Flow Cytometry (FACS)

Product Details anti-Periaxin Antibody (DyLight 488)

Binding Specificity: AA 1-91

Purpose: Anti-Human PRX DyLight® 488 conjugated Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Human PRX DyLight® 488 conjugated Antibody (ABIN5693300)-Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human.

Immunogen: E. coli-derived human PRX recombinant protein (Position: M1-K91).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells1. "Entrez Gene: PRX periaxin". 2. Gillespie CS, Sherman DL, Fleetwood-Walker SM, Cottrell DF, Tait S, Garry EM, Wallace VC, Ure J, Griffiths IR, Smith A, Brophy PJ (Jun 2000). "Peripheral demyelination and neuropathic pain behavior in periaxin-deficient mice". Neuron. 26 (2): 523-31.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Target Details for Periaxin

Target: Periaxin (PRX)

Alternative Name: PRX

Background:

Synonyms: Periaxin, PRX, KIAA1620

Tissue Specificity: Detected in spinal cord (PubMed:11133365). Isoform 1 and isoform 2 are found in sciatic nerve and Schwann cells (PubMed:11157804).

Background: Periaxin is a protein that in humans is encoded by the PRX gene. This gene encodes a protein involved in peripheral nerve myelin upkeep. The encoded protein contains 2 PDZ domains which were named after PSD95 (post synaptic density protein), DlgA (Drosophila disc large tumor suppressor), and ZO1 (a mammalian tight junction protein). Two alternatively spliced transcript variants have been described for this gene which encode different protein isoforms and which are targeted differently in the Schwann cell. Mutations in this gene cause Charcot-Marie-Tooth neuoropathy, type 4F and Dejerine-Sottas neuropathy.

Molecular Weight: 39 kDa

Gene ID: 57716