Periaxin antibody (AA 1-91) (DyLight 488)

Catalog No. ABIN7354670

Product Details anti-Periaxin Antibody (DyLight 488)

Target: Periaxin (PRX)

Binding Specificity: AA 1-91

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Periaxin antibody is conjugated to DyLight 488

Application: Flow Cytometry (FACS)

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG Polyclonal Anti-Human PRX Antibody DyLight® 488 Conjugated, Flow Validated.

Immunogen: E. coli-derived human PRX recombinant protein (Position: M1-K91).

Application Details

Application Notes:

Application Details: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: At 2-8°C for one year. Protect from light. Do not freeze.

Target Details for Periaxin

Target: Periaxin (PRX)

Alternative Name: PRX (PRX Products)

Synonyms: xprx antibody, MGC89167 antibody, CMT4F antibody, L-Periaxin antibody, periaxin antibody, prx antibody, PRX antibody, Prx antibody

Background:

Synonyms: Periaxin, PRX, KIAA1620

Tissue Specificity: Detected in spinal cord (PubMed:11133365). Isoform 1 and isoform 2 are found in sciatic nerve and Schwann cells (PubMed:11157804).

Background: Periaxin is a protein that in humans is encoded by the PRX gene. This gene encodes a protein involved in peripheral nerve myelin upkeep. The encoded protein contains 2 PDZ domains which were named after PSD95 (post synaptic density protein), DlgA (Drosophila disc large tumor suppressor), and ZO1 (a mammalian tight junction protein). Two alternatively spliced transcript variants have been described for this gene which encode different protein isoforms and which are targeted differently in the Schwann cell. Mutations in this gene cause Charcot-Marie-Tooth neuoropathy, type 4F and Dejerine-Sottas neuropathy.