BBS7 antibody
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- Target See all BBS7 Antibodies
- BBS7 (Bardet-Biedl Syndrome 7 (BBS7))
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This BBS7 antibody is un-conjugated
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Application
- ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
- Immunogen
- Bardet-Biedl syndrome 7
- Isotype
- IgG
- Top Product
- Discover our top product BBS7 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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human brain tissue were subjected to SDS PAGE followed by western blot with FNab00823(BBS7 antibody) at dilution of 1:1500
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze / thaw cycles.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- BBS7 (Bardet-Biedl Syndrome 7 (BBS7))
- Alternative Name
- BBS7 (BBS7 Products)
- Synonyms
- BBS7 antibody, bbs2l1 antibody, BBS2L1 antibody, id:ibd5048 antibody, zgc:153772 antibody, 8430406N16Rik antibody, Bardet-Biedl syndrome 7 antibody, bardet-biedl syndrome 7 antibody, Bardet-Biedl syndrome 7 L homeolog antibody, Bardet-Biedl syndrome 7 (human) antibody, BBS7 antibody, bbs7 antibody, MICPUN_100192 antibody, MICPUCDRAFT_16331 antibody, bbs7.L antibody, Bbs7 antibody
- Background
- Synonyms:BBS2L1 Background:The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor(GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog(SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization.
- Gene ID
- 55212
- UniProt
- Q8IWZ6
- Pathways
- Hedgehog Signaling
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