CDK5RAP3 antibody

Catalog No. ABIN5697307

Product Details anti-CDK5RAP3 Antibody

Target: CDK5RAP3 (CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDK5RAP3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Immunogen: CDK5 regulatory subunit associated protein 3

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

HeLa cells were subjected to SDS PAGE followed by western blot with FNab01560(CDK5RAP3 antibody) at dilution of 1:2000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for CDK5RAP3

Target: CDK5RAP3 (CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3))

Alternative Name: CDK5RAP3 (CDK5RAP3 Products)

Synonyms: cdkrap3 antibody, fb33h04 antibody, fc09c05 antibody, id:ibd2920 antibody, wu:fb33h04 antibody, wu:fc09c05 antibody, zgc:86863 antibody, CDK5RAP3 antibody, cdk5rap3 antibody, MGC82350 antibody, C53 antibody, HSF-27 antibody, IC53 antibody, LZAP antibody, MST016 antibody, OK/SW-cl.114 antibody, PP1553 antibody, 1810007E24Rik antibody, BC002318 antibody, C81486 antibody, CDK5 regulatory subunit associated protein 3 antibody, CDK5 regulatory subunit associated protein 3 L homeolog antibody, cdk5rap3 antibody, CDK5RAP3 antibody, cdk5rap3.L antibody, Cdk5rap3 antibody

Background: Synonyms:IC53, Background:Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation(PubMed:12054757, PubMed:12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation(PubMed:17785205, PubMed:20228063). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint(PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation(PubMed:16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress(PubMed:23152784). May also play a role in the rupture of the nuclear envelope during apoptosis(PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1(PubMed:21283629). (Microbial infection) May be negatively regulated by hepatitis B virus large envelope protein mutant pre-s2 to promote mitotic entry.

Molecular Weight: 65 kDa

Gene ID: 80279

UniProt: Q96JB5