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HTRA1 antibody

HTRA1 Reactivity: Human, Mouse, Rat WB, IHC, ELISA, IF, IP Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5699275
  • Target See all HTRA1 Antibodies
    HTRA1 (HtrA Serine Peptidase 1 (HTRA1))
    Reactivity
    • 59
    • 15
    • 11
    • 2
    • 2
    • 2
    • 1
    Human, Mouse, Rat
    Host
    • 61
    • 1
    Rabbit
    Clonality
    • 62
    Polyclonal
    Conjugate
    • 24
    • 8
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This HTRA1 antibody is un-conjugated
    Application
    • 45
    • 35
    • 26
    • 13
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)
    Immunogen
    HtrA serine peptidase 1
    Isotype
    IgG
    Top Product
    Discover our top product HTRA1 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Comment

    L02 cells were subjected to SDS PAGE followed by western blot with FNab04069(HTRA1 antibody) at dilution of 1:600

    Restrictions
    For Research Use only
  • Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze / thaw cycles.
    Storage
    -20 °C
    Expiry Date
    12 months
  • Target
    HTRA1 (HtrA Serine Peptidase 1 (HTRA1))
    Alternative Name
    HTRA1 (HTRA1 Products)
    Synonyms
    htra1 antibody, zgc:92029 antibody, zgc:172061 antibody, l56 antibody, htra antibody, Xhtra1 antibody, prss11 antibody, MGC145723 antibody, ARMD7 antibody, CARASIL antibody, HtrA antibody, L56 antibody, ORF480 antibody, PRSS11 antibody, AI429470 antibody, HTRA antibody, Prss11 antibody, RSPP11 antibody, HTRA1 antibody, HtrA serine peptidase 1a antibody, HtrA serine peptidase 1 antibody, HtrA serine peptidase 1b antibody, Serine protease HTRA1 antibody, HtrA serine peptidase 1 S homeolog antibody, htra1a antibody, HTRA1 antibody, htra1b antibody, htra1 antibody, Htra1 antibody, htra1.S antibody
    Background
    Synonyms:HTRA, PRSS11 Background:Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors(IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.
    Molecular Weight
    35 kDa, 50 kD, 42 kDa
    Gene ID
    5654
    UniProt
    Q92743
    Pathways
    Growth Factor Binding
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