OAS2 antibody
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- Target See all OAS2 Antibodies
- OAS2 (2'-5'-Oligoadenylate Synthetase 2, 69/71kDa (OAS2))
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This OAS2 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
- Immunogen
- 2'-5'-oligoadenylate synthetase 2, 69/71kDa
- Isotype
- IgG
- Top Product
- Discover our top product OAS2 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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Jurkat cells were subjected to SDS PAGE followed by western blot with FNab05951(OAS2 antibody) at dilution of 1:500
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze / thaw cycles.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- OAS2 (2'-5'-Oligoadenylate Synthetase 2, 69/71kDa (OAS2))
- Alternative Name
- OAS2 (OAS2 Products)
- Synonyms
- Oasl11 antibody, 2'-5'-oligoadenylate synthetase 2 antibody, 2'-5' oligoadenylate synthetase 2 antibody, 2'-5'-oligoadenylate synthetase 2, 69/71kDa antibody, OAS2 antibody, Oas2 antibody
- Background
- Synonyms: Background:Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates(2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L(RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.
- Molecular Weight
- 66-71 kDa
- Gene ID
- 4939
- UniProt
- P29728
- Pathways
- Hepatitis C
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