COPS3 antibody

Catalog No. ABIN5700531

Product Details anti-COPS3 Antibody

Target: COPS3 (COP9 Signalosome Complex Subunit 3 (COPS3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COPS3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Immunogen: COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

human brain tissue were subjected to SDS PAGE followed by western blot with FNab01871(COPS3 antibody) at dilution of 1:500

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for COPS3

Target: COPS3 (COP9 Signalosome Complex Subunit 3 (COPS3))

Alternative Name: COPS3 (COPS3 Products)

Synonyms: CG18332 antibody, CH3 antibody, Csn3 antibody, DCH3 antibody, Dch3 antibody, Dmel\\CG18332 antibody, FBgn0027055 antibody, dCSN3 antibody, COPS3 antibody, CSN3 antibody, DKFZp468P1922 antibody, Sgn3 antibody, wu:fc32a02 antibody, wu:fk59f01 antibody, zgc:111903 antibody, zgc:55643 antibody, zgc:77615 antibody, CONSTITUTIVE PHOTOMORPHOGENIC 13 antibody, COP9 SIGNALOSOME SUBUNIT 3 antibody, F18O22.40 antibody, F18O22_40 antibody, FUS11 antibody, FUSCA 11 antibody, SGN3 antibody, csn3 antibody, COP9 signalosome subunit 3 antibody, Proteasome component (PCI) domain protein antibody, COP9 signalosome subunit 3 L homeolog antibody, COP9 signalosome complex subunit 3 antibody, CSN3 antibody, cops3 antibody, COPS3 antibody, Cops3 antibody, COP13 antibody, cops3.L antibody, csn-3 antibody

Background: Synonyms:CSN3 Background:Component of the COP9 signalosome complex(CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin(Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Molecular Weight: 48 kDa

Gene ID: 8533

UniProt: Q9UNS2

Pathways: Cell Division Cycle