DIS3L2 antibody

Catalog No. ABIN5700727

Product Details anti-DIS3L2 Antibody

Target: DIS3L2 (DIS3-Like Exonuclease 2 (DIS3L2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DIS3L2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Immunogen: DIS3 mitotic control homolog (S. cerevisiae)-like 2

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for DIS3L2

Target: DIS3L2 (DIS3-Like Exonuclease 2 (DIS3L2))

Alternative Name: DIS3L2 (DIS3L2 Products)

Synonyms: RGD1560168 antibody, DIS3L2 antibody, DKFZp469O0522 antibody, FAM6A antibody, PRLMNS antibody, hDIS3L2 antibody, 4930429A22Rik antibody, 8030493P09Rik antibody, DIS3-like 3'-5' exoribonuclease 2 antibody, DIS3 like 3'-5' exoribonuclease 2 antibody, DIS3-like exonuclease 2 antibody, Dis3l2 antibody, DIS3L2 antibody, LOC100344728 antibody

Background: Synonyms:FAM6A Background:3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem(ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.

Molecular Weight: 65 kDa, 99 kDaa

Gene ID: 129563

UniProt: Q8IYB7

Pathways: Stem Cell Maintenance