EHD3 antibody

Catalog No. ABIN5700832

Product Details anti-EHD3 Antibody

Target: EHD3 (EH-Domain Containing 3 (EHD3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EHD3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Immunogen: EH-domain containing 3

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for EHD3

Target: EHD3 (EH-Domain Containing 3 (EHD3))

Alternative Name: EHD3 (EHD3 Products)

Synonyms: PAST3 antibody, Ehd2 antibody, EHD3 antibody, si:ch211-147c1.2 antibody, MGC146452 antibody, EH domain containing 3 antibody, EH-domain containing 3 antibody, EH domain containing 3 L homeolog antibody, EHD3 antibody, Ehd3 antibody, ehd3 antibody, ehd3.L antibody

Background: Synonyms:EHD2, Background:ATP-and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis(PubMed:25686250). In vitro causes tubulation of endocytic membranes(PubMed:24019528). Binding to phosphatidic acid induces its membrane tubulation activity(By similarity). Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment(ERC), retrograde early endosome to Golgi, and endosome to plasma membrane(rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology(PubMed:16251358, PubMed:17233914, PubMed:19139087, PubMed:23781025). Involved in the recycling of internalized D1 dopamine receptor(PubMed:21791287). Plays a role in cardiac protein trafficking probably implicating ANK2(PubMed:20489164). Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction(By similarity). In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function(By similarity). Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance(PubMed:23781025). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing(By similarity). Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis, possibly sharing redundant functions with EHD1(PubMed:25686250).

Molecular Weight: 61 kDa

Gene ID: 30845

UniProt: Q9NZN3