MAP3K3 antibody

Catalog No. ABIN5701066

Product Details anti-MAP3K3 Antibody

Target: MAP3K3 (Mitogen-Activated Protein Kinase Kinase Kinase 3 (MAP3K3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP3K3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Immunogen: mitogen-activated protein kinase kinase kinase 3

Isotype: IgG

Application Details

Application Notes: WB : 1:200-1:1000 IHC : 1:50-1:500

Comment:

mouse liver tissue were subjected to SDS PAGE followed by western blot with FNab09784( MAP3K3 Antibody) at dilution of 1:300

Restrictions: For Research Use only

Handling

Handling Advice: Avoid repeated freeze / thaw cycles.

Target Details for MAP3K3

Target: MAP3K3 (Mitogen-Activated Protein Kinase Kinase Kinase 3 (MAP3K3))

Alternative Name: MAP3K3 (MAP3K3 Products)

Synonyms: MAPKKK3 antibody, MEKK3 antibody, AW548911 antibody, Mekk3 antibody, mKIAA4031 antibody, mitogen activated protein kinase kinase kinase 3 antibody, mitogen-activated protein kinase kinase kinase 3 antibody, Map3k3 antibody, MAP3K3 antibody, map3k3 antibody

Background: Synonyms:MAP3K3, MAPK/ERK kinase kinase 3, MAPKKK3, MEK kinase 3, MEKK 3, MEKK3 Background:The mitogen-activated protein/ERK kinase kinase 3(MEKK3) is a member of a family of MEKK/Ste11 serine/threonine protein kinases. One function of MEKK3 is to serve as an upstream regulatory kinase in the mitogen-activated protein kinase cascade, however, it also plays a critical role in other signaling pathways. MEKK3 regulates several important functions including cell survival and proliferation. It is ubiquitously expressed in multiple tissues and has been found in complexes with scaffold proteins and other kinases.(PMID: 18206350).Cerebral cavernous malformations(CCMs) complex regulation of MEKK3 is essential during vertebrate heart development. MEKK3 signalling and KLF2/4 may be targeted to develop new CCM therapeutics.

Molecular Weight: 36kDa

UniProt: Q99759

Pathways: MAPK Signaling