VPS33A antibody

Catalog No. ABIN5701413

Product Details anti-VPS33A Antibody

Target: VPS33A (Vacuolar Protein Sorting 33 Homolog A (VPS33A))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VPS33A antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Immunogen: vacuolar protein sorting 33 homolog A (S. cerevisiae)

Isotype: IgG

Application Details

Application Notes: WB :1:500-1:5000,IP:1:200-1:2000

Comment:

human brain tissue were subjected to SDS PAGE followed by western blot with FNab09435(VPS33A antibody) at dilution of 1:500

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for VPS33A

Target: VPS33A (Vacuolar Protein Sorting 33 Homolog A (VPS33A))

Alternative Name: VPS33A (VPS33A Products)

Synonyms: r-Vps33a antibody, VPS33A antibody, vps33a antibody, MGC145524 antibody, 3830421M04Rik antibody, AI503300 antibody, AW048546 antibody, AW554476 antibody, bf antibody, im:7136893 antibody, wu:fc08g01 antibody, wu:fc26c10 antibody, VPS33A CORVET/HOPS core subunit antibody, VPS33A, CORVET/HOPS core subunit antibody, vacuolar protein sorting 33 homolog A (S. cerevisiae) antibody, Vacuolar protein sorting 33A antibody, VPS33A, CORVET/HOPS core subunit L homeolog antibody, vacuolar protein sorting 33A antibody, Vps33a antibody, VPS33A antibody, vps33a antibody, CGB_E2330C antibody, vps33a.L antibody

Background: Synonyms:FLJ22395, FLJ23187, hVPS33A, VPS33A Background:Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations(PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes, the function is dependent on its association with VPS16 but not VIPAS39(PubMed:25783203). The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG(PubMed:24554770).

Molecular Weight: 28kDa

Gene ID: 65082

UniProt: Q96AX1