VPS4B antibody
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- Target See all VPS4B (vps4b) Antibodies
- VPS4B (vps4b) (Vacuolar Protein Sorting 4 Homolog B (vps4b))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This VPS4B antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF)
- Immunogen
- vacuolar protein sorting 4 homolog B (S. cerevisiae)
- Isotype
- IgG
- Top Product
- Discover our top product vps4b Primary Antibody
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- Application Notes
- WB :1:500-1:5000,IP:1:500-1:5000,IF:1:10-1:100
- Comment
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Y79 cells were subjected to SDS PAGE followed by western blot with FNab09446(VPS4B antibody) at dilution of 1:500
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze / thaw cycles.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- VPS4B (vps4b) (Vacuolar Protein Sorting 4 Homolog B (vps4b))
- Alternative Name
- VPS4B (vps4b Products)
- Synonyms
- zgc:63682 antibody, vps4a antibody, SKD1 antibody, SKD1B antibody, VPS4-2 antibody, 8030489C12Rik antibody, Skd1 antibody, vacuolar protein sorting 4 homolog B antibody, vacuolar protein sorting 4 homolog B S homeolog antibody, vacuolar protein sorting 4b homolog B (S. cerevisiae) antibody, vacuolar protein sorting 4 homolog B (S. cerevisiae) antibody, vacuolar protein sorting 4B antibody, Vps4b antibody, vps4b.S antibody, vps4b antibody, VPS4B antibody
- Background
- Synonyms:MIG1, Protein SKD1, SKD1, VPS4 2, VPS42, VPS4B Background:Involved in late steps of the endosomal multivesicular bodies(MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles(ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding(HIV-1 and other lentiviruses). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan(PubMed:22660413).
- Molecular Weight
- 49kDa
- Gene ID
- 9525
- UniProt
- O75351
- Pathways
- Microtubule Dynamics, CXCR4-mediated Signaling Events
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