POLR3D antibody

Catalog No. ABIN5702365

Product Details anti-POLR3D Antibody

Target: POLR3D (Polymerase (RNA) III (DNA Directed) Polypeptide D, 44kDa (POLR3D))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POLR3D antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Immunogen: polymerase (RNA) III (DNA directed) polypeptide D, 44kDa

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for POLR3D

Target: POLR3D (Polymerase (RNA) III (DNA Directed) Polypeptide D, 44kDa (POLR3D))

Alternative Name: POLR3D (POLR3D Products)

Synonyms: 2810426M17Rik antibody, 44kDa antibody, AI326118 antibody, AW489084 antibody, BN51T antibody, RPC4 antibody, TSBN51 antibody, RPC53 antibody, RNA polymerase III subunit D antibody, polymerase (RNA) III (DNA directed) polypeptide D antibody, Polr3d antibody, POLR3D antibody

Background: Synonyms:BN51, BN51T Background:DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs(EBERs) induce type I interferon and NF-Kappa-B through the RIG-I pathway(By similarity).

Gene ID: 661

UniProt: P05423