CCDC98 antibody

Catalog No. ABIN5702623

Product Details anti-CCDC98 Antibody

Target: CCDC98 (FAM175A) (Family with Sequence Similarity 175, Member A (FAM175A))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCDC98 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Immunogen: family with sequence similarity 175, member A

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

human testis tissue were subjected to SDS PAGE followed by western blot with FNab02974(FAM175A antibody) at dilution of 1:500

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for CCDC98

Target: CCDC98 (FAM175A) (Family with Sequence Similarity 175, Member A (FAM175A))

Alternative Name: FAM175A (FAM175A Products)

Synonyms: CCDC98 antibody, abra1 antibody, ccdc98 antibody, fam175a antibody, ABRA1 antibody, 3830405G04Rik antibody, 5630400M01Rik antibody, AI506069 antibody, AL024423 antibody, AV118690 antibody, Ccdc98 antibody, RGD1305287 antibody, zgc:103522 antibody, abraxas 1, BRCA1 A complex subunit antibody, Coiled-coil domain-containing protein 98 antibody, BRCA1 A complex subunit antibody, family with sequence similarity 175 member A antibody, abraxas 2a, BRISC complex subunit antibody, abraxas 1, BRCA1 A complex subunit S homeolog antibody, ABRAXAS1 antibody, abraxas1 antibody, Abraxas1 antibody, FAM175A antibody, abraxas2a antibody, abraxas1.S antibody

Background: Synonyms:ABRA1, CCDC98 Background:Involved in DNA damage response and double-strand break(DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.

Molecular Weight: 46 kDa

Gene ID: 84142

UniProt: Q6UWZ7

Pathways: DNA Damage Repair, Positive Regulation of Response to DNA Damage Stimulus