FBXO6 antibody

Catalog No. ABIN5702804

Product Details anti-FBXO6 Antibody

Target: FBXO6 (F-Box Protein 6 (FBXO6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXO6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Immunogen: F-box protein 6

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

mouse liver tissue were subjected to SDS PAGE followed by western blot with FNab03048(FBXO6 antibody) at dilution of 1:300

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for FBXO6

Target: FBXO6 (F-Box Protein 6 (FBXO6))

Alternative Name: FBXO6 (FBXO6 Products)

Synonyms: FBG2 antibody, FBS2 antibody, FBX6 antibody, Fbx6b antibody, AA408845 antibody, Fbs2 antibody, Fbxo6b antibody, Fbg2 antibody, FBXO6 antibody, fbg2 antibody, fbs2 antibody, fbx6 antibody, fbx6b antibody, fbxo44 antibody, F-box protein 6 antibody, F-box protein 6 S homeolog antibody, FBXO6 antibody, Fbxo6 antibody, fbxo6.S antibody

Background: Synonyms:FBG2, FBS2, FBX6 Background:Substrate-recognition component of some SCF(SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway(ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1(phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.

Molecular Weight: 35 kDa

Gene ID: 26270

UniProt: Q9NRD1