HMHA1 antibody

Catalog No. ABIN5702949

Product Details anti-HMHA1 Antibody

Target: HMHA1 (Histocompatibility (Minor) HA-1 (HMHA1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HMHA1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Immunogen: histocompatibility (minor) HA-1

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Jurkat cells were subjected to SDS PAGE followed by western blot with FNab03935(HMHA1 antibody) at dilution of 1:800

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for HMHA1

Target: HMHA1 (Histocompatibility (Minor) HA-1 (HMHA1))

Alternative Name: HMHA1 (HMHA1 Products)

Synonyms: RGD1308662 antibody, MGC80108 antibody, hmha1 antibody, arhgap45 antibody, ha-1 antibody, HMHA1 antibody, DKFZp469A2018 antibody, ARHGAP45 antibody, HA-1 antibody, HLA-HA1 antibody, 6330406L22Rik antibody, AW539505 antibody, Ha-1 antibody, Rho GTPase activating protein 45 antibody, Rho GTPase activating protein 45 L homeolog antibody, histocompatibility (minor) HA-1 b antibody, Arhgap45 antibody, ARHGAP45 antibody, arhgap45.L antibody, hmha1b antibody, arhgap45 antibody

Background: Synonyms:KIAA0223 Background:GTPase activator for the Rho-type GTPases. Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens(mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease(GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation(BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte(CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL.

Molecular Weight: 140-150 kDa

Gene ID: 23526

UniProt: Q92619