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KPNA5 antibody

KPNA5 Reactivity: Human, Mouse, Rat WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5703033
  • Target See all KPNA5 Antibodies
    KPNA5 (Karyopherin alpha 5 (Importin alpha 6) (KPNA5))
    Reactivity
    • 28
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 27
    • 1
    Rabbit
    Clonality
    • 27
    • 1
    Polyclonal
    Conjugate
    • 18
    • 2
    • 2
    • 2
    • 2
    • 2
    This KPNA5 antibody is un-conjugated
    Application
    • 27
    • 20
    • 7
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Immunogen
    karyopherin alpha 5 (importin alpha 6)
    Isotype
    IgG
    Top Product
    Discover our top product KPNA5 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze / thaw cycles.
    Storage
    -20 °C
    Expiry Date
    12 months
  • Target
    KPNA5 (Karyopherin alpha 5 (Importin alpha 6) (KPNA5))
    Alternative Name
    KPNA5 (KPNA5 Products)
    Synonyms
    IPOA6 antibody, SRP6 antibody, Ipoa6 antibody, im:7151662 antibody, zgc:110662 antibody, karyopherin subunit alpha 5 antibody, karyopherin alpha 5 (importin alpha 6) antibody, KPNA5 antibody, Kpna5 antibody, kpna5 antibody
    Background
    Synonyms: Background:Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex(NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and-beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
    Molecular Weight
    60 kDa
    Gene ID
    3841
    UniProt
    O15131
    Pathways
    Protein targeting to Nucleus
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