LRWD1 antibody

Catalog No. ABIN5703091

Product Details anti-LRWD1 Antibody

Target: LRWD1 (Leucine-Rich Repeat and WD Repeat-Containing Protein 1 (LRWD1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRWD1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Immunogen: leucine-rich repeats and WD repeat domain containing 1

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for LRWD1

Target: LRWD1 (Leucine-Rich Repeat and WD Repeat-Containing Protein 1 (LRWD1))

Alternative Name: LRWD1 (LRWD1 Products)

Synonyms: CENP-33 antibody, ORCA antibody, 1200011O22Rik antibody, AU042569 antibody, AW548074 antibody, Orca antibody, si:dkey-261j4.9 antibody, wu:fb78b03 antibody, wu:ft31b04 antibody, leucine rich repeats and WD repeat domain containing 1 antibody, leucine-rich repeats and WD repeat domain containing 1 antibody, microRNA 5090 antibody, leucine-rich repeats and WD repeat domain containing 1 L homeolog antibody, LRWD1 antibody, Lrwd1 antibody, lrwd1 antibody, MIR5090 antibody, lrwd1.L antibody

Background: Synonyms:CENP-33, ORCA Background:Required for G1/S transition. Recruits and stabilizes the origin recognition complex(ORC) onto chromatin during G1 to establish pre-replication complex(preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.

Molecular Weight: 85 kDa

Gene ID: 222229

UniProt: Q9UFC0

Pathways: Chromatin Binding