FBXW5 antibody
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- Target See all FBXW5 Antibodies
- FBXW5 (F-Box and WD Repeat Domain Containing 5 (FBXW5))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This FBXW5 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Immunogen
- F-box and WD repeat domain containing 5
- Isotype
- IgG
- Top Product
- Discover our top product FBXW5 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab03056( FBXW5 Antibody) at dilution of 1:600
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze / thaw cycles.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- FBXW5 (F-Box and WD Repeat Domain Containing 5 (FBXW5))
- Alternative Name
- FBXW5 (FBXW5 Products)
- Synonyms
- Fbw5 antibody, AI159739 antibody, F-box and WD repeat domain containing 5 antibody, F-box and WD-40 domain protein 5 antibody, FBXW5 antibody, Fbxw5 antibody
- Background
- Synonyms:FBW5 Background:Substrate recognition component of both SCF(SKP1-CUL1-F-box protein) and DCX(DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B(IL1B) signaling pathway.
- Molecular Weight
- 65 kDa
- Gene ID
- 54461
- UniProt
- Q969U6
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