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PAF1/PD2 antibody

PAF1 Reactivity: Human WB, ELISA, IHC, IP Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5704209
  • Target See all PAF1/PD2 (PAF1) Antibodies
    PAF1/PD2 (PAF1) (Paf1, RNA Polymerase II Associated Factor, Homolog (PAF1))
    Reactivity
    • 40
    • 16
    • 13
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 40
    Rabbit
    Clonality
    • 39
    • 1
    Polyclonal
    Conjugate
    • 19
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PAF1/PD2 antibody is un-conjugated
    Application
    • 25
    • 19
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)
    Immunogen
    Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
    Isotype
    IgG
    Top Product
    Discover our top product PAF1 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Comment

    HepG2 cells were subjected to SDS PAGE followed by western blot with FNab06106(PAF1 antibody) at dilution of 1:1000

    Restrictions
    For Research Use only
  • Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze / thaw cycles.
    Storage
    -20 °C
    Expiry Date
    12 months
  • Target
    PAF1/PD2 (PAF1) (Paf1, RNA Polymerase II Associated Factor, Homolog (PAF1))
    Alternative Name
    PAF1 (PAF1 Products)
    Synonyms
    F23149_1 antibody, PD2 antibody, 5730511K23Rik antibody, AA675045 antibody, f23149_1 antibody, pd2 antibody, im:6906070 antibody, paf1l antibody, wu:fb80a09 antibody, paf1 antibody, RGD1306219 antibody, PAF1 homolog, Paf1/RNA polymerase II complex component antibody, Paf1, RNA polymerase II complex component antibody, PAF1 homolog, Paf1/RNA polymerase II complex component L homeolog antibody, RNA polymerase II-associated factor 1 homolog pseudogene antibody, RNA polymerase II-associated factor 1 homolog antibody, paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) antibody, Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) antibody, PAF1 antibody, Paf1 antibody, paf1 antibody, paf1.L antibody, LOC100019208 antibody, LOC100161171 antibody, LOC100639019 antibody, LOC100650306 antibody
    Background
    Synonyms:PD2 Background:Component of the PAF1 complex(PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'-and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1, it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4'(H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B(H2BK120ub1), UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the RNF20/40 E3 ubiquitin-protein ligase complex. Involved in polyadenylation of mRNA precursors. Has oncogenic activity in vivo and in vitro.
    Gene ID
    54623
    UniProt
    Q8N7H5
    Pathways
    Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance
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