ZC3HAV1 antibody

Catalog No. ABIN5705199

Product Details anti-ZC3HAV1 Antibody

Target: ZC3HAV1 (Zinc Finger CCCH-Type, Antiviral 1 (ZC3HAV1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZC3HAV1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Immunogen: zinc finger CCCH-type, antiviral 1

Isotype: IgG

Application Details

Application Notes: WB:1:1000-1:10000,IHC:1:20-1:200,IP:1:1000-1:10000

Comment:

HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab09606( ZC3HAV1 Antibody) at dilution of 1:4000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for ZC3HAV1

Target: ZC3HAV1 (Zinc Finger CCCH-Type, Antiviral 1 (ZC3HAV1))

Alternative Name: ZC3HAV1 (ZC3HAV1 Products)

Synonyms: 1200014N16Rik antibody, 2900058M19Rik antibody, 9130009D18Rik antibody, 9830115L13Rik antibody, ARTD13 antibody, D6Bwg1452e antibody, ZAP antibody, Zap antibody, FLB6421 antibody, PARP13 antibody, ZC3H2 antibody, ZC3HDC2 antibody, zinc finger CCCH type, antiviral 1 antibody, zinc finger CCCH-type containing, antiviral 1 antibody, Zc3hav1 antibody, ZC3HAV1 antibody

Background: Synonyms:DKFZp686F2052, DKFZp686H1869, DKFZp686O19171, FLB6421, FLJ13288, ZAP, ZC3H2, ZC3HAV1, ZC3HDC2, Zinc finger antiviral protein Background:Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element(ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72(DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1(HIV-1), moloney and murine leukemia virus(MoMLV) and xenotropic MuLV-related virus(XMRV), filoviridae: ebola virus(EBOV) and marburg virus(MARV), togaviridae: sindbis virus(SINV) and Ross river virus(RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes(ISGs).

Molecular Weight: 34kDa

Gene ID: 56829

UniProt: Q7Z2W4