RGMA antibody

Catalog No. ABIN5705218

Product Details anti-RGMA Antibody

Target: RGMA (RGM Domain Family, Member A (RGMA))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RGMA antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunoprecipitation (IP)

Immunogen: RGM domain family, member A

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for RGMA

Target: RGMA (RGM Domain Family, Member A (RGMA))

Alternative Name: RGMA (RGMA Products)

Synonyms: RGM antibody, BC059072 antibody, C230063O06 antibody, repulsive guidance molecule family member a antibody, repulsive guidance molecule family member A antibody, RGMA antibody, Rgma antibody

Background: Synonyms:RGM Background:Member of the repulsive guidance molecule(RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein(BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

Gene ID: 56963

UniProt: Q96B86

Pathways: Tube Formation