ALKBH7 antibody

Catalog No. ABIN5705608

Product Details anti-ALKBH7 Antibody

Target: ALKBH7 (AlkB, Alkylation Repair Homolog 7 (ALKBH7))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALKBH7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Immunogen: alkB, alkylation repair homolog 7 (E. coli)

Isotype: IgG

Application Details

Application Notes: WB :1:200-1:2000,IHC:1:20-1:200

Comment:

human testis tissue were subjected to SDS PAGE followed by western blot with FNab00315(ALKBH7 antibody) at dilution of 1:500

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for ALKBH7

Target: ALKBH7 (AlkB, Alkylation Repair Homolog 7 (ALKBH7))

Alternative Name: ALKBH7 (ALKBH7 Products)

Synonyms: ABH7 antibody, SPATA11 antibody, UNQ6002 antibody, 2310045B01Rik antibody, 2510008E23Rik antibody, Abh7 antibody, Spata11 antibody, alkB homolog 7 antibody, Alkbh7 antibody, ALKBH7 antibody

Background: Synonyms:ABH7, ALKBH7, SPATA11, UNQ6002 Background:May function as protein hydroxylase, can catalyze auto-hydroxylation at Leu-110(in vitro), but this activity may be due to the absence of the true substrate(PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death(PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage(PubMed:23666923). Does not display DNA demethylase activity(PubMed:23666923). Involved in fatty acid metabolism(By similarity).

Molecular Weight: 25kDa

Gene ID: 84266

UniProt: Q9BT30