MYH11 antibody

Catalog No. ABIN5707514

Product Details anti-MYH11 Antibody

Target: MYH11 (Myosin Heavy Chain 11, Smooth Muscle (MYH11))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MYH11 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Purified

Purity: Protein A affinity chromatography

Immunogen: Recombinant human protein was used as the immunogen for the recombinant SMMHC antibody.

Clone: MYH11-2303R

Isotype: IgG kappa

Application Details

Application Notes: Optimal dilution of the recombinant SMMHC antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Prediluted IHC only format: incubate for 30 min at RT (1)

Restrictions: For Research Use only

Handling

Buffer: Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, *For IHC use only*

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the recombinant SMMHC antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for MYH11

Target: MYH11 (Myosin Heavy Chain 11, Smooth Muscle (MYH11))

Alternative Name: SMMHC (Smooth Muscle Myosin Heavy Chain) (MYH11 Products)

Synonyms: AV071570 antibody, SM1 antibody, SM2 antibody, smMHC antibody, AAT4 antibody, FAA4 antibody, SMHC antibody, SMMHC antibody, myosin antibody, myh11 antibody, myosin, heavy polypeptide 11, smooth muscle antibody, myosin heavy chain 11 antibody, myosin, heavy chain 11, smooth muscle antibody, myosin, heavy chain 11a, smooth muscle antibody, Myh11 antibody, MYH11 antibody, myh11a antibody

Background: Smooth muscle myosin heavy chain (SM-MHC) is a cytoplasmic structural protein, which is a major component of the contractile apparatus in smooth muscle cells. Expression of smooth muscle myosin is developmentally regulated, appearing early in smooth muscle development, and is specific for smooth muscle development. Two isoforms of smooth muscle myosin heavy chain have been identified, designated MHC-1 and MHC-2. The antibody may be useful for the study of breast tumors as the presence of an intact layer of myoepithelial cells is an important feature, which may distinguish benign breast lesions and carcinoma in situ from invasive tumors.