GALNS antibody

Catalog No. ABIN5708456

Product Details anti-GALNS Antibody

Target: GALNS (Galactosamine (N-Acetyl)-6-Sulfate Sulfatase (GALNS))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GALNS antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity purified

Immunogen: A recombinant human partial protein corresponding to amino acids Y181-N289 was used as the immunogen for the GALNS antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the GALNS antibody should be determined by the researcher.\. Western Blot: 0.5-1 μg/mL,IHC (FFPE): 1-2 μg/mL,Direct ELISA: 0.1-0.5 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the GALNS antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for GALNS

Target: GALNS (Galactosamine (N-Acetyl)-6-Sulfate Sulfatase (GALNS))

Alternative Name: GALNS (GALNS Products)

Synonyms: GALNAC6S antibody, GAS antibody, GalN6S antibody, MPS4A antibody, mFLJ00319 antibody, galns antibody, zgc:158385 antibody, galactosamine (N-acetyl)-6-sulfatase antibody, galactosamine (N-acetyl)-6-sulfate sulfatase antibody, N-acetylgalactosamine-6-sulfatase antibody, galactosamine (N-acetyl)-6-sulfatase L homeolog antibody, GALNS antibody, Galns antibody, Celly_0425 antibody, galns.L antibody, galns antibody

Background: N-acetylgalactosamine-6-sulfatase is an enzyme that, in humans, is encoded by the GALNS gene. This gene encodes N-acetylgalactosamine-6-sulfatase which is a lysosomal exohydrolase required for the degradation of the glycosaminoglycans, keratan sulfate, and chondroitin 6-sulfate. Sequence alterations including point, missense and nonsense mutations, as well as those that affect splicing, result in a deficiency of this enzyme. Deficiencies of this enzyme lead to Morquio A syndrome, a lysosomal storage disorder.

UniProt: P34059

Pathways: Glycosaminoglycan Metabolic Process