Prothrombin antibody

Catalog No. ABIN5708472

Product Details anti-Prothrombin Antibody

Target: Prothrombin (F2) (Coagulation Factor II (thrombin) (F2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Prothrombin antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity purified

Immunogen: A recombinant human partial protein corresponding to amino acids Y97-R124 was used as the immunogen for the Prothrombin antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Prothrombin antibody should be determined by the researcher.\. Western Blot: 0.5-1 μg/mL,IHC (FFPE): 1-2 μg/mL,Direct ELISA: 0.1-0.5 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the Prothrombin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for Prothrombin

Target: Prothrombin (F2) (Coagulation Factor II (thrombin) (F2))

Alternative Name: Prothrombin (F2 Products)

Synonyms: PT antibody, RPRGL2 antibody, THPH1 antibody, Cf-2 antibody, Cf2 antibody, FII antibody, thrombin antibody, zgc:66319 antibody, wu:fb57c10 antibody, wu:fd42e09 antibody, wu:fd59d01 antibody, prothrombin antibody, F2 antibody, coagulation factor II, thrombin antibody, coagulation factor II antibody, coagulation factor II (thrombin) antibody, F2 antibody, f2 antibody

Background: F2 (Coagulation Factor II), also known as prothrombin, is a serine protease that in humans is encoded by the F2 gene. This gene for human prothrombin (F2) was assigned to chromosome 11p11-q12 by analysis of a panel of somatic cell hybrid DNAs and by in situ hybridization, using both cDNA and genomic probes. The activated thrombin enzyme plays an important role in hemostasis and thrombosis: it converts fibrinogen to fibrin for blood clot formation, stimulates platelet aggregation, and activates coagulation factors V, VIII (F8), and XIII (F13A1). Thrombin also inhibits coagulation by activating protein C.

UniProt: P00734

Pathways: Complement System, Peptide Hormone Metabolism, Regulation of G-Protein Coupled Receptor Protein Signaling