Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 6 (SLC17A6) (AA 250-300) antibody

Details for Product No. ABIN571638
Antigen
Epitope
AA 250-300
26
10
7
3
3
3
1
1
1
1
1
1
1
1
Reactivity
Human, Rat (Rattus), Mouse (Murine)
75
67
64
2
1
Host
Rabbit
55
32
8
Clonality
Polyclonal
Conjugate
Un-conjugated
5
4
4
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
76
54
26
24
24
13
5
5
2
2
2
1
Options
Immunogen A synthetic peptide from aa region 250-300 of human VGluT2 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
Specificity Specific for VGLUT2.
Purification Whole serum
Antigen
Alternative Name VGluT2 (SLC17A6 Antibody Abstract)
Background Function: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane, Multi-pass membrane protein. Cell junction, synapse, synaptosome.
Tissue specificity: Expressed in brain. Expressed in hippocampal neurons (at protein level).
Developmental stage: Expressed in brain throughout development. Transiently expressed in hippocampal neurons during the first week after birth, with expression decreasing thereafter.
Miscellaneous: Mice lacking this protein exhibit an elevated rate of perinatal lethality. Surviving animals display a strong reduction in evoked glutamergic responses in thalamic neurons. Reduction of protein level in homozygous and heterozygous knockouts leads to a graded reduction in the amplitude of the postsynaptic response to single vesicle fusion in thalamic neurons, consistent with a role for this protein in determining quantal size. Also known as: Vesicular glutamate transporter 2, VGlU2, Solute carrier family 17 member 6, Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter, Differentiation-associated BNPI, Slc17a6, Dnpi.
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Comment

The ag is located in aa region of 200-300 of the parental protein.

Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Supplier Images
Image no. 1 for anti-Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 6 (SLC17A6) (AA 250-300) antibody (ABIN571638) IHC on mouse brain (cryo section) using Rabbit antibody to VGluT2 at 1 : 500 dilutio...
Image no. 2 for anti-Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 6 (SLC17A6) (AA 250-300) antibody (ABIN571638) IHC on mouse brain (cryo section) using Rabbit antibody to VGluT2 at 1 : 500 dilutio...
Image no. 3 for anti-Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 6 (SLC17A6) (AA 250-300) antibody (ABIN571638) IHC on mouse brain (cryo section) using Rabbit antibody to VGluT2 at 1 : 500 dilutio...
Image no. 4 for anti-Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 6 (SLC17A6) (AA 250-300) antibody (ABIN571638) Rat brain lysate
Image no. 5 for anti-Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 6 (SLC17A6) (AA 250-300) antibody (ABIN571638) IHC on mouse brain (cryo section) using Rabbit antibody to VGluT2 at 1 : 500 dilutio...
Image no. 6 for anti-Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 6 (SLC17A6) (AA 250-300) antibody (ABIN571638) IHC on mouse brain (cryo section) using Rabbit antibody to VGluT2 at 1 : 500 dilutio...