TRPC4 antibody

Catalog No. ABIN571659

Product Details anti-TRPC4 Antibody

Target: TRPC4 (Transient Receptor Potential Cation Channel, Subfamily C, Member 4 (TRPC4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRPC4 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Specificity: Specific for TRPC4. See also the immunogen.

Immunogen: A synthetic peptide from human TRPC4 conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in many other species.

Isotype: IgG

Application Details

Application Notes: A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute in 150 µL of sterile water. Centrifuge to remove any insoluble material.

Handling Advice: Avoid freeze and thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date: 12 months

Target Details for TRPC4

Target: TRPC4 (Transient Receptor Potential Cation Channel, Subfamily C, Member 4 (TRPC4))

Alternative Name: TRPC4 (TRPC4 Products)

Synonyms: TRPC5 antibody, TRPC4 antibody, HTRP-4 antibody, HTRP4 antibody, TRP4 antibody, CCE1 antibody, STRPC4 antibody, Trp4 antibody, Trrp4 antibody, transient receptor potential cation channel subfamily C member 4 antibody, short transient receptor potential channel 4 antibody, transient receptor potential cation channel, subfamily C, member 4 antibody, TRPC4 antibody, LOC100538928 antibody, trpc4 antibody, Trpc4 antibody

Background: Function: Thought to form non-selective a receptor-activated calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion.
Subunit: Isoform alpha but not isoform beta associates with inositol-1,4,5-triphosphate receptor (ITPR). Interacts with NHERF.
Subcellular location: Membrane, Multi-pass membrane protein. -
Tissue specificity: Abundantly expressed in brain (hippocampal CA1 pyramidal neurons, dentate gyrus granule cells, and cerebral cortical neurons, and in the septal nuclei and the mitral layer ofolfactory bulb). Lower levels are detected in other tissues. -
Tissue specificity: Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain. Also known as: Short transient receptor potential channel 4, TrpC4, Trp4, Capacitative calcium entry channel 1, CCE1, Trrp4, Receptor-activated cation channel TRP4, Trp-related protein 4, hTrp-4, hTrp4.