ADAM22 antibody (ADAM Metallopeptidase Domain 22) (Cytoplasmic Domain) Primary Antibody
- Binding Specificity
- Cytoplasmic Domain
- Human, Mouse
- Immunohistochemistry (IHC), Western Blotting (WB)
- Specific for ADAM22.
- Whole serum
- A synthetic peptide from cytoplasmic domain of mouse ADAM22 (Metalloproteinase-disintegrin ADAM22-3) conjugated to an immunogenic carrier protein was used as the antigen.
- Alternative Name
- ADAM22 (ADAM22 Antibody Abstract)
- Function: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1.
Subcellular location: Membrane, Single-pass type I membrane protein
Tissue specificity: Highly expressed in the brain and in some high-grade but not low-grade gliomas. Detected slightly or not at all in other tissues. Also known as: Disintegrin and metalloproteinase domain-containing protein 22, Metalloproteinase disintegrin ADAM22-3, Metalloproteinase like, disintegrin like, and cysteine-rich protein 2, MDC2.
- Application Notes
- A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
- For Research Use only
- Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
- Handling Advice
- Avoid freeze and thaw cycles.
- 4 °C/-20 °C
- Storage Comment
- Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
- Expiry Date
- 12 months