CHRNA10 antibody (C-Term)

Catalog No. ABIN571796

Product Details anti-CHRNA10 Antibody

Target: CHRNA10 (Cholinergic Receptor, Nicotinic, alpha 10 (CHRNA10))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHRNA10 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Specificity: Specific for CHRNA10.

Cross-Reactivity: Human

Cross-Reactivity (Details): Other species not yet tested but expected to work in rat and mouse.

Purification: Whole serum

Immunogen: A synthetic peptide from c-terminal region of human Neuronal acetylcholine receptor subunit alpha-10 conjugated to blue carrier protein was used as the antigen. The antigen shares 85% identity with mouse and rat sequences.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute in 100 μL of sterile water. Centrifuge to remove any insoluble material.

Handling Advice: Avoid freeze and thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date: 12 months

Target Details for CHRNA10

Target: CHRNA10 (Cholinergic Receptor, Nicotinic, alpha 10 (CHRNA10))

Alternative Name: CHRNA10 (CHRNA10 Products)

Synonyms: si:dkey-24p1.3 antibody, ALPHA 10 nAChR antibody, cholinergic receptor, nicotinic, alpha polypeptide 10 antibody, cholinergic receptor nicotinic alpha 10 subunit antibody, cholinergic receptor, nicotinic, alpha 10a antibody, neuronal acetylcholine receptor subunit alpha-10 antibody, cholinergic receptor, nicotinic, alpha 10 (neuronal) antibody, Chrna10 antibody, CHRNA10 antibody, chrna10a antibody, LOC100344381 antibody

Background: FUNCTION: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. Subcellular location: Cell membrane, Multi-pass membrane protein. Cell junction âÄ° synapse âÄ° postsynaptic cell membrane, Multi-pass membrane protein. Tissue specificity: Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes.,Auditory,ACH10, Neuronal acetylcholine receptor subunit alpha-10, Nicotinic acetylcholine receptor subunit alpha-10, NACHR alpha-10, NACHRA10

UniProt: Q9GZZ6

Pathways: Sensory Perception of Sound, Synaptic Membrane