Contactin 1 antibody (AA 100-150)

Catalog No. ABIN571798

Product Details anti-Contactin 1 Antibody

Target: Contactin 1 (CNTN1)

Binding Specificity: AA 100-150

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Contactin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificity: Specific for contactin-1.

Cross-Reactivity: Human, Rat

Cross-Reactivity (Details): Other species not yet tested.

Purification: IgG

Immunogen: A synthetic peptide from AA 100-150 of human contactin 1 conjugated to an immunogenic carrier protein was used as the antigen.

Isotype: IgG

Application Details

Application Notes: IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.

Handling Advice: Avoid freeze and thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date: 12 months

Target Details for Contactin 1

Target: Contactin 1 (CNTN1)

Alternative Name: Contactin 1 (CNTN1 Products)

Synonyms: F3 antibody, GP135 antibody, AW495098 antibody, CNTN antibody, F3cam antibody, F3/F11 antibody, cntn-A antibody, F11 antibody, CNTN1 antibody, cntn1 antibody, contactin 1 antibody, contactin 1 L homeolog antibody, contactin 1a antibody, CNTN1 antibody, Cntn1 antibody, cntn1.L antibody, cntn1a antibody

Background: FUNCTION: Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth. SUBUNIT: Monomer. Interacts with CNTNAP1 in cis form. Binds to the carbonic-anhydrase like domain of protein-tyrosine phosphatase zeta. Interacts with NOTCH1 and TNR. SUBCELLULAR LOCATION: Cell membrane, Lipid-anchor, GPI-anchor. MISCELLANEOUS: F3 shares with L1, N-CAM, MAG, and other cell adhesion molecules from nervous tissue the L2/HNK-1 carbohydrate epitope. TISSUE SPECIFICITY: Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle.,Contactin Family,Neural cell surface protein F3, F3cam, contactin 1, CNTN1, Glycoprotein gp135

UniProt: Q12860