ABCB4 antibody (AA 1-110)

Catalog No. ABIN6136350

Product Details anti-ABCB4 Antibody

Target: ABCB4 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 (ABCB4))

Binding Specificity: AA 1-110

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABCB4 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: MDLEAAKNGT AWRPTSAEGD FELGISSKQK RKKTKTVKMI GVLTLFRYSD WQDKLFMSLG TIMAIAHGSG LPLMMIVFGE MTDKFVDTAG NFSFPVNFSL SLLNPGKILE

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human ABCB4 (NP_061337.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-ABCB4 antibody (ABIN6136350)

Yang, Wei, Xia, Liu, Chen, Zhang, Li, Feng, Yu, Zhang, Qu, Xu, Mao, Fan, Ma: "Formononetin ameliorates cholestasis by regulating hepatic SIRT1 and PPARα." in: Biochemical and biophysical research communications, Vol. 512, Issue 4, pp. 770-778, (2020) (PubMed).

Target Details for ABCB4

Target: ABCB4 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4 (ABCB4))

Alternative Name: ABCB4 (ABCB4 Products)

Synonyms: ABC21 antibody, GBD1 antibody, ICP3 antibody, MDR2 antibody, MDR2/3 antibody, MDR3 antibody, PFIC-3 antibody, PGY3 antibody, zgc:172149 antibody, Mdr2 antibody, Pgy-2 antibody, Pgy2 antibody, mdr-2 antibody, Pgy3 antibody, ABCB4a antibody, DEFB1 antibody, PGP2 antibody, PGY2 antibody, PGP3 antibody, ABCB4 antibody, RUNDC3B antibody, ATP binding cassette subfamily B member 4 antibody, ATP-binding cassette, sub-family B (MDR/TAP), member 4 antibody, beta-defensin 1-like antibody, ATP-binding cassette, sub-family B (MDR/TAP), member 1B antibody, RUN domain-containing protein 3B antibody, ABCB4 antibody, abcb4 antibody, Abcb4 antibody, LOC100861170 antibody, Abcb1b antibody, LOC101122517 antibody

Background: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined, however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function.,ABCB4,ABC21,GBD1,ICP3,MDR2,MDR2/3,MDR3,PFIC-3,PGY3,Cancer,Signal Transduction,Endocrine & Metabolism,Lipid Metabolism,ABCB4

Molecular Weight: 135 kDa/140 kDa/141 kDa

Gene ID: 5244

UniProt: P21439

Pathways: Regulation of Lipid Metabolism by PPARalpha