ASIP antibody (AA 23-132)

Catalog No. ABIN6137196

Product Details anti-ASIP Antibody

Target: ASIP (Agouti Signaling Protein (ASIP))

Binding Specificity: AA 23-132

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ASIP antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: HLPPEEKLRD DRSLRSNSSV NLLDVPSVSI VALNKKSKQI GRKAAEKKRS SKKEASMKKV VRPRTPLSAP CVATRNSCKP PAPACCDPCA SCQCRFFRSA CSCRVLSLNC

Cross-Reactivity: Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 23-132 of human ASIP (NP_001663.2).

Isotype: IgG

Application Details

Application Notes: IHC,1:50 - 1:100,IF,1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ASIP

Target: ASIP (Agouti Signaling Protein (ASIP))

Alternative Name: ASIP (ASIP Products)

Background: In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes.,ASIP,AGSW,AGTI,AGTIL,ASP,SHEP9,Signal Transduction,Cell Biology & Developmental Biology,Growth factor,Endocrine & Metabolism,Insulin Receptor Signaling Pathway,Neuroscience,ASIP

Molecular Weight: 14 kDa

Gene ID: 434

UniProt: P42127

Pathways: Cell-Cell Junction Organization, Feeding Behaviour