Claudin 18 antibody (AA 20-80)

Catalog No. ABIN6138681

Product Details anti-Claudin 18 Antibody

Target: Claudin 18 (CLDN18)

Binding Specificity: AA 20-80

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claudin 18 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GCIAATGMDM WSTQDLYDNP VTSVFQYEGL WRSCVRQSSG FTECRPYFTI LGLPAMLQAV R

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-80 of human CLDN18 (NP_057453.1).

Isotype: IgG

Application Details

Application Notes: WB,1:1000 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Claudin 18

Target: Claudin 18 (CLDN18)

Alternative Name: CLDN18 (CLDN18 Products)

Synonyms: claudin-18 antibody, CLDN18 antibody, SFTA5 antibody, SFTPJ antibody, claudin 18 L homeolog antibody, claudin 18 antibody, cldn18.L antibody, CLDN18 antibody, Cldn18 antibody

Background: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.,CLDN18,SFTA5,SFTPJ,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Tight Junctions,Cytoskeleton,CLDN18

Molecular Weight: 27 kDa

Gene ID: 51208

UniProt: P56856

Pathways: Cell-Cell Junction Organization, Hepatitis C