Casein Kinase 1 gamma 2 antibody (AA 316-415)

Catalog No. ABIN6139122

Product Details anti-Casein Kinase 1 gamma 2 Antibody

Target: Casein Kinase 1 gamma 2 (CSNK1G2) (Casein Kinase 1, gamma 2 (CSNK1G2))

Binding Specificity: AA 316-415

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Casein Kinase 1 gamma 2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: FDRSGFVFDY EYDWAGKPLP TPIGTVHTDL PSQPQLRDKT QPHSKNQALN STNGELNADD PTAGHSNAPI TAPAEVEVAD ETKCCCFFKR RKRKSLQRHK

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 316-415 of human CSNK1G2 (NP_001310.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Casein Kinase 1 gamma 2

Target: Casein Kinase 1 gamma 2 (CSNK1G2) (Casein Kinase 1, gamma 2 (CSNK1G2))

Alternative Name: CSNK1G2 (CSNK1G2 Products)

Synonyms: CK1g2 antibody, 2810429I12Rik antibody, AI463719 antibody, CKI antibody, ck1-gamma antibody, CSNK1G2 antibody, ck1g2 antibody, csnk1g2 antibody, fj97g11 antibody, wu:fj97g11 antibody, wz8345 antibody, zgc:110719 antibody, zgc:153415 antibody, casein kinase 1 gamma 2 antibody, casein kinase 1, gamma 2 antibody, casein kinase 1 gamma 2 L homeolog antibody, casein kinase 1, gamma 2a antibody, casein kinase 1, gamma 2b antibody, CSNK1G2 antibody, Csnk1g2 antibody, csnk1g2.L antibody, csnk1g2 antibody, csnk1g2a antibody, csnk1g2b antibody

Background: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.,CSNK1G2,CK1g2,Cancer,Signal Transduction,Kinase,Endocrine & Metabolism,Lipid Metabolism,Stem Cells,CSNK1G2

Molecular Weight: 47 kDa

Gene ID: 1455

UniProt: P78368

Pathways: Hedgehog Signaling