ERCC2 antibody (AA 1-300)

Catalog No. ABIN6140265

Product Details anti-ERCC2 Antibody

Target: ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2))

Binding Specificity: AA 1-300

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERCC2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: MRELKRTLDA KGHGVLEMPS GTGKTVSLLA LIMAYQRAYP LEVTKLIYCS RTVPEIEKVI EELRKLLNFY EKQEGEKLPF LGLALSSRKN LCIHPEVTPL RFGKDVDGKC HSLTASYVRA QYQHDTSLPH CRFYEEFDAH GREVPLPAGI YNLDDLKALG RRQGWCPYFL ARYSILHANV VVYSYHYLLD PKIADLVSKE LARKAVVVFD EAHNIDNVCI DSMSVNLTRR TLDRCQGNLE TLQKTVLRIK ETDEQRLRDE YRRLVEGLRE ASAARETDAH LANPVLPDEV LQEAVPGSIR

Cross-Reactivity: Human, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human XPD/XPD/ERCC2 (NP_001124339.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ERCC2

Target: ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2))

Alternative Name: ERCC2 (ERCC2 Products)

Synonyms: COFS2 antibody, EM9 antibody, TTD antibody, XPD antibody, AA407812 antibody, AU020867 antibody, AW240756 antibody, CXPD antibody, Ercc-2 antibody, MGC89573 antibody, CG9433 antibody, DhR3 antibody, DhXPD antibody, DmXPD antibody, Dmel\\CG9433 antibody, ERCC2 antibody, XPD/ERCC2 antibody, l(2)SH2 2137 antibody, l(2)SH2137 antibody, xpd antibody, zgc:56365 antibody, ERCC excision repair 2, TFIIH core complex helicase subunit antibody, excision repair cross-complementing rodent repair deficiency, complementation group 2 antibody, excision repair cross-complementation group 2 antibody, Xeroderma pigmentosum D antibody, ERCC2 antibody, Ercc2 antibody, ercc2 antibody, Xpd antibody

Background: The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.,ERCC2,COFS2,EM9,TFIIH,TTD,TTD1,XPD,Epigenetics & Nuclear Signaling,DNA Damage & Repair,Cell Biology & Developmental Biology,Apoptosis,ERCC2

Molecular Weight: 46 kDa/86 kDa

Gene ID: 2068

UniProt: P18074

Pathways: DNA Damage Repair