GTF2H4 antibody (AA 1-300)

Catalog No. ABIN6141508

Product Details anti-GTF2H4 Antibody

Target: GTF2H4 (General Transcription Factor IIH, Polypeptide 4, 52kDa (GTF2H4))

Binding Specificity: AA 1-300

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GTF2H4 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MESTPSRGLN RVHLQCRNLQ EFLGGLSPGV LDRLYGHPAT CLAVFRELPS LAKNWVMRML FLEQPLPQAA VALWVKKEFS KAQEESTGLL SGLRIWHTQL LPGGLQGLIL NPIFRQNLRI ALLGGGKAWS DDTSQLGPDK HARDVPSLDK YAEERWEVVL HFMVGSPSAA VSQDLAQLLS QAGLMKSTEP GEPPCITSAG FQFLLLDTPA QLWYFMLQYL QTAQSRGMDL VEILSFLFQL SFSTLGKDYS VEGMSDSLLN FLQHLREFGL VFQRKRKSRR YYPTRLAINL SSGVSGAGGT

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human GTF2H4 (NP_001508.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for GTF2H4

Target: GTF2H4 (General Transcription Factor IIH, Polypeptide 4, 52kDa (GTF2H4))

Alternative Name: GTF2H4 (GTF2H4 Products)

Synonyms: gtf2h4.2 antibody, tfb2 antibody, tfiih antibody, DDBDRAFT_0191833 antibody, DDBDRAFT_0231037 antibody, DDB_0191833 antibody, DDB_0231037 antibody, AW545633 antibody, BTF2 p52 antibody, TFIIH antibody, p44 antibody, p52 antibody, wu:fa04h09 antibody, zgc:77721 antibody, P52 antibody, TFB2 antibody, gtf2h4.1 antibody, discoidin domain receptor tyrosine kinase 1 antibody, general transcription factor IIH subunit 4 antibody, TFIIH subunit antibody, valine--tRNA ligase, mitochondrial antibody, general transcription factor II H, polypeptide 4 antibody, general transcription factor 2H subunit 4 antibody, general transcription factor IIH, polypeptide 4 antibody, general transcription factor IIH subunit 4 S homeolog antibody, general transcription factor IIH, polypeptide 4, 52kDa antibody, DDR1 antibody, GTF2H4 antibody, gtf2h4 antibody, LOC100351754 antibody, Gtf2h4 antibody, gtf2h4.S antibody

Background: Component of the general transcription and DNA repair factor IIH (TFIIH core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.,GTF2H4,P52,TFB2,TFIIH,Epigenetics & Nuclear Signaling,DNA Damage & Repair,GTF2H4

Molecular Weight: 24 kDa/52 kDa

Gene ID: 2968

UniProt: Q92759

Pathways: DNA Damage Repair