LAMTOR1 antibody (AA 1-161)

Catalog No. ABIN6143083

Product Details anti-LAMTOR1 Antibody

Target: LAMTOR1 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 1 (LAMTOR1))

Binding Specificity: AA 1-161

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LAMTOR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)

Sequence: MGCCYSSENE DSDQDREERK LLLDPSSPPT KALNGAEPNY HSLPSARTDE QALLSSILAK TASNIIDVSA ADSQGMEQHE YMDRARQYST RLAVLSSSLT HWKKLPPLPS LTSQPHQVLA SEPIPFSDLQ QVSRIAAYAY SALSQIRVDA KEELVVQFGI P

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-161 of human LAMTOR1 (NP_060377.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:1000,IHC,1:50 - 1:100,IF,1:50 - 1:100

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for LAMTOR1

Target: LAMTOR1 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 1 (LAMTOR1))

Alternative Name: LAMTOR1 (LAMTOR1 Products)

Synonyms: C11orf59 antibody, PDRO antibody, Ragulator1 antibody, p18 antibody, p27RF-Rho antibody, 2400001E08Rik antibody, Pdro antibody, C15H11orf59 antibody, c11orf59 antibody, flj20625 antibody, p27rf-rho antibody, pdro antibody, ragulator1 antibody, late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 antibody, late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 S homeolog antibody, LAMTOR1 antibody, Lamtor1 antibody, lamtor1.S antibody

Background: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.,LAMTOR1,C11orf59,PDRO,Ragulator1,p18,p27RF-Rho,Signal Transduction,Kinase,PI3K-Akt Signaling Pathway,Cell Biology & Developmental Biology,Autophagy,Endocrine & Metabolism,Lipid Metabolism,Cholesterol Metabolism,Cardiovascular,Lipids,Regulator of mTOR complex function,Regulators,LAMTOR1

Molecular Weight: 17 kDa

Gene ID: 55004

UniProt: Q6IAA8