NOTCH4 antibody (AA 1824-2003)

Catalog No. ABIN6144740

Product Details anti-NOTCH4 Antibody

Target: NOTCH4 (Notch 4 (NOTCH4))

Binding Specificity: AA 1824-2003

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NOTCH4 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: PPEARHKATP GREAGPFPRA RTVSVSVPPH GGGALPRCRT LSAGAGPRGG GACLQARTWS VDLAARGGGA YSHCRSLSGV GAGGGPTPRG RRFSAGMRGP RPNPAIMRGR YGVAAGRGGR VSTDDWPCDW VALGACGSAS NIPIPPPCLT PSPERGSPQL DCGPPALQEM PINQGGEGKK

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1824-2003 of human NOTCH4 (NP_004548.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for NOTCH4

Target: NOTCH4 (Notch 4 (NOTCH4))

Alternative Name: NOTCH4 (NOTCH4 Products)

Background: This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.,NOTCH4,INT3,notch 4,Epigenetics & Nuclear Signaling,Transcription Factors,Signal Transduction,Cell Biology & Developmental Biology,Notch Signaling Pathway,ESC Pluripotency and Differentiation,Stem Cells,Cardiovascular,Angiogenesis,Heart,Cardiogenesis,NOTCH4

Molecular Weight: 39 kDa/61 kDa/209 kDa

Gene ID: 4855

UniProt: Q99466

Pathways: Notch Signaling