Factor VIII antibody

Catalog No. ABIN614478

Product Details anti-Factor VIII Antibody

Target: Factor VIII (F8) (Coagulation Factor VIII (F8))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Factor VIII antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody recognizes full-length Human Factor VIII (F8). Does not cross-react with von Willebrand factor.

Purification: Protein G chromatography

Immunogen: F8 antibody was raised against purified human Factor VIII.

Clone: N-a

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.73 mg/mL

Buffer: PBS, pH 7.4

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody at -20 °C to -70 °C.

Target Details for Factor VIII

Target: Factor VIII (F8) (Coagulation Factor VIII (F8))

Abstract: F8 Products

Synonyms: fb61d02 antibody, wu:fb61d02 antibody, Cf-8 antibody, Cf8 antibody, FVIII antibody, AHF antibody, DXS1253E antibody, F8B antibody, F8C antibody, HEMA antibody, coagulation factor VIIi antibody, coagulation factor VIII antibody, coagulation factor VIII, procoagulant component antibody, f7i antibody, F8 antibody

Background: This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation, factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.Synonyms: AHF, Antihemophilic factor, F8C, Procoagulant component

Gene ID: 2157

NCBI Accession: NP_000123

UniProt: P00451