NPR1 antibody (AA 260-470)

Catalog No. ABIN6144783

Product Details anti-NPR1 Antibody

Target: NPR1 (Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1))

Binding Specificity: AA 260-470

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NPR1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: EAGLCGEDYV FFHLDIFGQS LQGGQGPAPR RPWERGDGQD VSARQAFQAA KIITYKDPDN PEYLEFLKQL KHLAYEQFNF TMEDGLVNTI PASFHDGLLL YIQAVTETLA HGGTVTDGEN ITQRMWNRSF QGVTGYLKID SSGDRETDFS LWDMDPENGA FRVVLNYNGT SQELVAVSGR KLNWPLGYPP PDIPKCGFDN EDPACNQDHL S

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 260-470 of human NPR1 (NP_000897.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for NPR1

Target: NPR1 (Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1))

Alternative Name: NPR1 (NPR1 Products)

Synonyms: ANPRA antibody, ANPa antibody, GUC2A antibody, GUCY2A antibody, NPRA antibody, Anpra antibody, Gca antibody, NPR-A antibody, Npra antibody, sGC antibody, si:dkey-27c15.1 antibody, AI893888 antibody, GC-A antibody, Pndr antibody, ARABIDOPSIS NONEXPRESSER OF PR GENES 1 antibody, ATNPR1 antibody, F15H21.6 antibody, F15H21_6 antibody, NIM1 antibody, NON-INDUCIBLE IMMUNITY 1 antibody, NONEXPRESSER OF PR GENES 1 antibody, REGULATORY PROTEIN NPR1 antibody, SAI1 antibody, SALICYLIC ACID INSENSITIVE 1 antibody, natriuretic peptide receptor 1 antibody, natriuretic peptide receptor 1a antibody, regulatory protein (NPR1) antibody, NPR1 antibody, Npr1 antibody, npr1a antibody

Background: Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides, they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2, MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009],NPR1,ANPRA,ANPa,GUC2A,GUCY2A,NPRA,Signal Transduction,G protein signaling,G-Protein-Coupled Receptors(GPCR),Cardiovascular,Angiogenesis,Blood,Blood Pressure regulation,NPR1

Molecular Weight: 118 kDa

Gene ID: 4881

UniProt: P16066