PCSK1 antibody (AA 604-753)

Catalog No. ABIN6145322

Product Details anti-PCSK1 Antibody

Target: PCSK1 (Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1))

Binding Specificity: AA 604-753

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCSK1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: PRVYTSYNTV QNDRRGVEKM VDPGEEQPTQ ENPKENTLVS KSPSSSSVGG RRDELEEGAP SQAMLRLLQS AFSKNSPPKQ SPKKSPSAKL NIPYENFYEA LEKLNKPSQL KDSEDSLYND YVDVFYNTKP YKHRDDRLLQ ALVDILNEEN

Cross-Reactivity: Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 604-753 of human PCSK1 (NP_000430.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PCSK1

Target: PCSK1 (Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1))

Alternative Name: PCSK1 (PCSK1 Products)

Synonyms: BMIQ12 antibody, NEC1 antibody, PC1 antibody, PC3 antibody, SPC3 antibody, Nec-1 antibody, Nec1 antibody, Phpp-1 antibody, BDP antibody, PC1/3 antibody, proprotein convertase subtilisin/kexin type 1 antibody, prohormone convertase 1 antibody, PCSK1 antibody, Pcsk1 antibody, pcsk1 antibody, PC1B antibody

Background: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. The protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene,PCSK1,BMIQ12,NEC1,PC1,PC3,SPC3,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Growth factor,Ubiquitin,Endocrine & Metabolism,Neuroscience,PCSK1

Molecular Weight: 79 kDa/84 kDa

Gene ID: 5122

UniProt: P29120

Pathways: Peptide Hormone Metabolism